Complex DNA assembly

Dynamic DNA device

Application

Complex DNA assembly

The capability of de novo design of molecules with precise weights, geometries, and functions provides an important avenue not only for scientific explorations, but also for technological applications. Owing largely to its rationalizable design strategies, supermolecular self-assembly with DNA has emerged as a powerful approach in design, and assemble custom-shaped intricate three-dimensional nanostructures with molecular weights up to several megadaltons.The basic principle of DNA-tile self-assembly is to design the building blocks — DNA strands — that can self-assemble to prescribed shaped through Watson-Crick base-pairing. We have used DNA-tile and DNA-origami self-assembly to build both discrete 2D/3D objects and extended 2D crystals. These DNA-assembly methods are the cornerstones of our research.

Dynamic DNA device


Functional structure